VDRs have become indispensable tools in an international business environment that is dependent on the seamless exchange of sensitive data. Virtual data rooms are used to speed up due diligence in M&A transactions. They offer key features such as controlled document access as well as activity tracking features that facilitate research and establish trust between all parties involved.
In this study, we show that VDR is essential for the morphogenetic process that controls hair cycle growth and cell division in the hair follicle (HF). We identify VDR as a crucial regulator of catagen and show that the Vdr cKO phenotype is the result of impaired apoptosis of the epithelial strands that are dying in the hair follicle during the catagen phase. This delay in entry of the HF into anagen leads to alopecia. the HF turns into a dermal cyst made of epidermal cells.
To study the role of VDR in the regulation of apoptosis in catagen, we conducted a comprehensive screen for putative VDR targets using functional annotation enrichment analysis. In comparison to the control CO fibroblasts we found 268 genes that are upregulated by the unliganded VDR and downregulated by activation of 1,25D. The majority of these genes are increased by fibroblasts of WT.
The security that the VDR provides is critical to its effectiveness. Make sure the VDR you select has custom permission controls and two-step authentication to protect against password theft audit logs, secure browser connections and 24-hour monitoring to give your team the peace of mind that their data is secure from threats of any kind.